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Small amounts of cocaine usually make the user feel euphoric, energetic, talkative, mentally alert, and hypersensitive to sight, sound, and touch.
The drug can also temporarily decrease the need for food and sleep. The faster the drug is absorbed, the more intense the resulting high, but also the shorter its duration. Snorting cocaine produces a relatively slow onset of the high, but it may last from 15 to 30 minutes.
In contrast, the high from smoking is more immediate but may last only 5 to 10 minutes. Short-term physiological effects of cocaine use include constricted blood vessels; dilated pupils; and increased body temperature, heart rate, and blood pressure. Some cocaine users report feelings of restlessness, irritability, anxiety, panic, and paranoia.
Severe medical complications can occur with cocaine use. Some of the most frequent are cardiovascular effects, including disturbances in heart rhythm and heart attacks; neurological effects, including headaches, seizures, strokes, and coma; and gastrointestinal complications, including abdominal pain and nausea. Cocaine-related deaths are often a result of cardiac arrest or seizures 2 see " National Overdose Deaths: of Deaths from Cocaine ".
Many cocaine users also use alcohol, and this combination can be particularly dangerous.
The two substances react to produce cocaethylene, which may potentiate the toxic effects of cocaine and alcohol on the heart. Users combine these drugs because the stimulating effects of cocaine are offset by the sedating effects of heroin; however, this can lead to taking a high dose of heroin without initially realizing it.
Because cocaine's effects wear off sooner, this can lead to a heroin overdose, in which the user's respiration dangerously slows down or stops, possibly fatally. National Institutes of Health. Drug Topics.
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The short and long-term effects of cocaine on the body